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Symbol
Name
ID 		Vangl2
VANGL planar cell polarity 2
MGI:2135272
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Spinal dysraphism
Disease(s) Associated with VANGL2
neural tube defect

Mouse Phenotypes
nervous system phenotype
abnormal neural plate morphology
abnormal neural tube morphology
abnormal embryonic neuroepithelium morphology
enlarged floor plate
abnormal neural tube closure
delayed neural tube closure
open neural tube
spina bifida
craniorachischisis
abnormal cochlear hair cell morphology
increased cochlear hair cell number
increased cochlear outer hair cell number
abnormal orientation of inner hair cell stereociliary bundles
abnormal orientation of cochlear hair cell stereociliary bundles
abnormal orientation of outer hair cell stereociliary bundles
abnormal cochlear inner hair cell morphology
abnormal cochlear outer hair cell morphology
abnormal vestibular hair cell morphology
abnormal brain morphology
abnormal brain development
abnormal cervical flexure morphology
abnormal forebrain development
abnormal midbrain development
abnormal brain ventricular system morphology
abnormal brain ventricle morphology
enlarged lateral ventricles
enlarged third ventricle
abnormal lateral ventricle morphology
abnormal corpus callosum morphology
abnormal midbrain morphology
abnormal forebrain morphology
abnormal dorsal striatum morphology
abnormal hippocampus morphology
abnormal cerebral hemisphere morphology
abnormal hindbrain morphology
abnormal metencephalon morphology
exencephaly
Availability Mouse Genotype
Vangl2em1(IMPC)Mbp/Vangl2em1(IMPC)Mbp
Vangl2Lp-m1Jus/Vangl2Lp-m1Jus
Vangl2Lp/Vangl2Lp *
Vangl2ska17/Vangl2ska17
Vangl2tm1.2Mdea/Vangl2tm1.2Mdea !
Vangl2tm1.2Yy/Vangl2tm1.2Yy
Vangl2tm2.2Mdea/Vangl2tm2.2Mdea
Vangl2Lp-2J/Vangl2+
Vangl2Lp/Vangl2+ *! !
Vangl2Lp/Vangl2Lp-m1Jus
Vangl2Lp/Vangl2ska17
Vangl2Lp/Vangl2tm1.2Mdea
Vangl2M1Yzcm/Vangl2+
Tg(Pax2-cre)1Akg/0
Vangl2tm1.2Mdea/Vangl2tm2.1Mdea  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory